Educational Overview

Pulmonary arterial hypertension (PAH) is a rare disease with significant consequences, including serious functional impairment and premature death. If left untreated, PAH is rapidly fatal. Fortunately, over the past decade, the knowledge and understanding of this disease has greatly expanded. Furthermore, the availability of effective and more convenient oral and inhaled medications has allowed clinicians to better individualize therapy to meet patient treatment goals. Though there is no cure for PAH, effective treatment can significantly slow disease progression and clinical worsening. Given the serious nature of this disease and its rapid progression, optimal management approaches are essential.

Optimal management of patients with PAH requires early detection and diagnosis followed by a patient-centered treatment plan. Given the complex and individualized nature of PAH therapy, pharmacists must have a full understanding of treatment algorithms, disease-specific therapies, and long-term monitoring recommendations based on evidence-based guidelines. As the armamentarium to treat PAH continues to expand, pharmacists must make efforts to stay informed of the latest finding in order to contribute to the optimal management of these patients.

Target Audience

This continuing pharmacy education activity is planned to meet the needs of pharmacists in a variety of practice settings, including large and small health systems, outpatient clinics, managed-care organizations, long-term care facilities, and academia. This program will target health-system pharmacists who are responsible for the safe and effective use of medications utilized for the treatment of patients with PAH.

Learning Objectives

Upon completing this activity, participants will be able to:

  • Discuss the pathophysiology of PAH
  • Compare the safety and efficacy among the various classes of medications used in the treatment of PAH
  • Utilize evidence-based guidelines to select appropriate therapy to meet individualized patient treatment goals

Educational Format

This online activity is based on a series of live programs held in conjunction with State Societies of Health-System Pharmacists (SHPs) Annual Meetings.This activity is divided into five episodes:

  • Episode 1: Major Issues and Challenges of Hospital Pharmacists when Managing Patients with PAH
  • Episode 2: Pathophysiology of PAH
  • Episode 3: Knowing Your Therapeutic Options: Current Medications and Their Effectiveness
  • Episode 4: Utilizing Treatment Algorithms in Your Practice
  • Episode 5: Addressing the Challenges in PAH Management


  Heather R. Bream-Rouwenhorst, PharmD, BCPS
Clinical Assistant Professor
University of Iowa College of Pharmacy
Clinical Pharmacy Specialist – Cardiology
University of Iowa Hospitals and Clinics
Iowa City, IA

  James C. Coons, PharmD, BCPS (AQ Cardiology)
Associate Professor
University of Pittsburgh School of Pharmacy
Cardiology Residency Program Director
Clinical Pharmacist, Cardiology
University of Pittsburgh Medical Center-Presbyterian Hospital
Pittsburgh, PA

  Rebekah L. Hanson, PharmD, BCPS, BCACP
Clinical Pharmacist, Specialty Pharmacy Services
Clinical Assistant Professor
UIC College of Pharmacy
University of Illinois Hospital and Health Sciences System
Department of Pharmacy Practice
Chicago, IL

  Roberto F. Machado, MD
Associate Professor of Medicine
Section of Pulmonary, Critical Care Medicine, Sleep and Allergy
Institute for Personalized Respiratory Medicine
University of Illinois at Chicago College of Medicine
Chicago, IL


ACPE logoCenter for Independent Healthcare Education is accredited by the Accreditation Council for Pharmacy Education as a provider for continuing pharmacy education. Center has assigned 2.0 contact hours (0.2 CEUs) of continuing pharmacy education credits for participating in this activity.

ACPE UAN:  0473-9999-13-002-H01-P
Activity type: Knowledge-based

For questions regarding the accreditation of this activity, please contact us at

Method of Participation and Instruction for Credit

  1. Review the entire CE information including target audience, learning objectives, and disclosures.
  2. Review each episode.
  3. Complete the Post Test, Evaluation, and Credit Application Form.
  4. Please note that to receive credit you must achieve a score of at least 70%.
  5. Mail the completed Post Test, Evaluation, and Credit Application Form to Vemco MedEd, 245 US Highway 22, Suite 304, Bridgewater, NJ 08807 or fax to (908) 235-4222 or email to
  6. The information that you participated will be uploaded to CPEMonitor and you will be able to access your credits from the profile you set up with NABP. For more information, please visit

Disclosure of Conflicts of Interest Policy

In accordance with policies set forth by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), Center for Independent Healthcare Education requires all faculty members and planning committee with an opportunity to affect the content of a continuing education activity to disclose any relevent financial relationships during the past 12 months with commercial interests. A commercial interest is any entity producing, marketing, reselling or distributing health care goods or services consumed by or used on patients. Relationships with commercial interests and conflicts of interest resulting from those relationships must be revealed to the audience and resolved prior to the activity.

Relevant relationships include roles such as speaker, author, consultant, independent contractor (including research), employee, investor, advisory committee member, board member, review panelist, and investigator. If a potential speaker or author indicates a possible conflict of interest, the conflict will be resolved by choosing another speaker or author for that topical area, or the slides, handouts, and/or monograph will be reviewed and approved by a qualified commercially-disinterested peer.

Planning Committee Members
Heather R. Bream-Rouwenhorst, PharmD, BCPS
James C. Coons, PharmD
Rebekah L. Hanson, PharmD, BCPS, BCACP
Roberto F. Machado, MD
Paul DeLisle
Marco P. Cicero, PhD
Maja Drenovac, PharmD


Disclosure of Financial Interest Summary

Heather R. Bream-Rouwenhorst, PharmD, BCPS (Faculty/Planner) has no relevant financial relationships with commercial interests. Dr. Bream-Rouwenhorst does not intend to discuss the off-label use of a product.

James C. Coons, PharmD (Faculty/Planner) has no relevant financial relationships with commercial interests. Dr. Coons does not intend to discuss the off-label use of a product.

Roberto F. Machado, MD (Faculty/Planner) has relevant financial relationships with commercial interests as follows:
  • Advisory Board: Gilead Sciences
  • Grant Recipient/Research Support: NIH, Actelion, United Therapeutics
Dr. Machado does intend to discuss the use of imatinib for PAH treatment.

Rebekah L. Hanson, PharmD, BCPS, BCACP (Faculty/Planner) has no relevant financial relationships with commercial interests. Dr. Hanson does not intend to discuss the off-label use of a product.

No other speakers, authors, planners or content reviewers have any relevant financial relationships to disclose.

Content review confirmed that the content was developed in a fair, balanced manner free from commercial bias. Disclosure of a relationship is not intended to suggest or condone commercial bias in any presentation, but it is made to provide participants with information that might be of potential importance to their evaluation of a presentation.


This activity is jointly sponsored by Center for Independent Healthcare Education
and Vemco MedEd.


Commercial Support
This activity is supported by an educational grant from
Actelion Pharmaceuticals, US, Inc. and Gilead Sciences, Inc.

There is no fee to participate in this activity.

Hardware/Software Requirements
Microsoft Internet Explorer, Mozilla Firefox, Apple Safari or Google Chrome with the QuickTime Plug-in
Note: Please disable any “pop-up blocker” features.

Adobe® Reader version 7 or above to view PDF files (If you do not have Adobe® Reader, you can download it for free from
Adobe Flash Player version 10 or above to view multimedia content (If you do
not have Adobe Flash Player, you can download it for free from

Connection Speed
Cable, DSL, or better of at least 300 kbps

System Check
Please e-mail any questions or concerns to

Copyright Statement
Copyright © 2013 Vemco MedEd, LLC. All Rights Reserved. Permission for accreditation use granted to Center for Independent Healthcare Education.

Privacy Policy

Episode 1 Episode 2 Episode 3 Episode 4 Episode 5